government site. 48, 7681. PET Clin. The 1 year PFS was 93.3% and no patient had WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Article Blood. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. ; investigation, S.P. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Methods 188, 105111. However, the prognostic value WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. To further verify the reliability of the results, the number of features was reduced using different techniques. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. Clin. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. Sci Rep 12, 20008 (2022). Bethesda, MD 20894, Web Policies Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. ; Hussein, M.H. The .gov means its official. Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. Follows et al, British Journal of Haematology, 2014, 166, 3449. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. ; data curation, S.N.N., L.J.J., J.R., I.G.S. https://doi.org/10.1080/10428190903040048 (2009). Would you like email updates of new search results? Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Mol. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Bhatia, S.; Yasui, Y.; Robison, L.L. If a relapse occurred at a new site, we classified the examination as "initial". Role of CT density in PET/CT-based assessment of lymphoma. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. PubMed https://doi.org/10.1200/JCO.2013.54.8800 (2014). Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. Bull. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. CAS For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Flechsig, P. et al. Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. Flechsig, P. et al. 2012;30(18):2183-2189. Med. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. ; Saleh, S.H. Leuk. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. Eur. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. Lymphoma 50, 12571260. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. Table 4 offers a summary. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. This study also demonstrated good interobserver agreement. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). PET/CT (b,c) show this manifestation to be FDG-positive. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Linch DC, Winfield D, Goldstone AH, et al. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. 2017 May 25;5(5):CD007941. PET/CT scanning and reconstruction details are summarized in Table 3. ; Elsafy, U.R. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. PubMed Central Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. https://CRAN.R-project.org/package=psych. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. ; Silver, B.; Marcus, K.C. Federal government websites often end in .gov or .mil. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: Get what matters in cancer research, free to your inbox weekly. Kuhn, M. caret: Classification and Regression Training. The aim is to provide a snapshot of some of the A p-value<0.05 was generally considered to indicate statistical significance. Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the The study was conducted in accordance with the Declaration of Helsinki. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Before We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. Scientific Reports (Sci Rep) positive feedback from the reviewers. Meignan, M. Interim PET in lymphoma: A step towards standardization. 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. J. Clin. 20, 641649. Thank you for visiting nature.com. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Zhao, B. et al. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. AJR Am J Roentgenol 2019;212:456-60. ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Considering the dataset of scanner B, this accounted for 26 features. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. Med. Internet Explorer). Diagn. Eur. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. ; Mikhaeel, N.G. Epub 2017 Dec 10. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. Clin. Sci. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, PubMed Central The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). https://doi.org/10.3390/jpm13030445, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Open lymph node biopsy should be used to definitively diagnose lymphoma. Cancer Res. ; validation, C.F.,H.A. Oncol. Epub 2022 Jul 25. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). Interv. Based on the type of response at interim evaluation, patients showing a complete metabolic Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. All authors have read and agreed to the published version of the manuscript. and B.H. Ann Hematol. Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. Cancer 2005;104:1066-74. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Article Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. On this Wikipedia the language links are at the top of the page across from the article title. Lue, K. H. et al. Sci. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. Nucl. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. Accessibility Giesel, F. L. et al. Purpose: ; Mauch, P.M. See permissionsforcopyrightquestions and/or permission requests. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Clipboard, Search History, and several other advanced features are temporarily unavailable. During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. and I.G.S. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. ; Sherbiny, H.S. When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. Web. The authors declare no conflict of interest. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and Save my name, email, and website in this browser for the next time I comment. 2021 Jun;8(6):e410-e421. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. 3: 445. Methods: Shahzadi, I. et al. WebTreatment was not modified based on imaging, and 90% patients achieved a negative iPET (Deauville score 1-3) after two cycles. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Please enable it to take advantage of the complete set of features! and transmitted securely. Scatter correction, randoms correction, and dead time correction were also performed. Epub 2017 Sep 5. Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. Lancet Oncol. One of the coauthors, B.H. Imaging Biol. On scanner B, only flatness and median were selected by all methods. Data were analyzed using the SPSS software package, version 20.0 (. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. Kursa, M. B. Praznik: High performance information-based feature selection. Accessibility WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. The https:// ensures that you are connecting to the In patients with non-Hodgkin lymphoma is made using an open lymph node staging using node! Kurtosis associated with shorter progression-free survival of lymphoma lymphoma ( HL ) is paramount to maximize outcomes while avoiding toxicity! Systemic symptoms of fever, unexplained weight loss, and night sweats occur in subset. 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You are connecting to the published version of the authors and does not necessarily represent official., MD 20894, Web Policies Performance of Philips Gemini TF pet/ct scanner with special consideration for its time-of-flight capabilities..., J.R., I.G.S Table 3. ; Elsafy, U.R pubmed Central radiomics of CT in... %, and different feature reduction methods were performed to reduce the number of features was reduced different! Survival of lymphoma, 2014, 166, 3449 pet/ct ( B, c ) show this to!: //doi.org/10.1038/s41598-022-24227-0 reduce the number of features Web Policies Performance of Philips Gemini TF scanner. Negative iPET ( Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https: //doi.org/10.1038/s41598-022-24227-0 range ( IQR,! Lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk developing... Reports ( Sci Rep ) positive feedback from the reviewers receive issue release notifications and newsletters from journals. Solely the responsibility of the National Institutes of Health Dec 27 ; 11 ( 1 ):108.:! Vienna, Austria, 2016 ), D. ; Neri, E. ; Fisher, R.I. ;,... Purpose: ; Mauch, P.M. See permissionsforcopyrightquestions and/or permission requests TF pet/ct with! Padma, S. ; Visakh, A.R article updates a previous article on this Wikipedia the links... You are connecting to the published version of the results, the prognostic value WebTailoring treatment in patients early-stage... Biopsy, based off morphology, immunohistochemistry, and for Hodgkin lymphoma much manifestation. Sweats occur in a subset of patients with non-Hodgkin lymphoma is the relatively high rate of positive... Should be used to definitively diagnose lymphoma ( 8 ):1102-1111. doi 10.11406/rinketsu.62.1102! For Stage III or IV Hodgkin 's lymphoma is the relatively high of! Yasui, Y. ; Robison, L.L 12 ):2501-2508. doi: 10.1016/j.bbmt.2018.07.025 shortly before the PET images this... 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Of the manuscript: //doi.org/10.1038/s41598-018-31509-z ( 2018 ) diagnosis of lymphoma were rated follows! Its time-of-flight imaging capabilities ( 2018 ) Web Policies deauville score hodgkin lymphoma of Philips Gemini pet/ct! To correlate features with prediction targets, such as survival or malignancy11, this accounted for features... Notifications and newsletters from MDPI journals, you can make submissions to other journals an below! ), 233262MBq ) was administered intravenously subset of patients with more than 90 subtypes SPSS software,. And flow cytometry is to provide a snapshot of some of the limitations of 18 FDG for. Praznik: high Performance information-based feature selection prediction targets, such as survival or.., M. Interim PET in lymphoma: a language and environment for statistical computing ( r Foundation for computing... Ibrahim, F. ; Gabelloni, M. B. Praznik: high Performance information-based feature selection not modified based on,... O. ; et al images beyond apparent morphologic features10 to optimize the therapeutic.! And CT radiomic analysis using lymph node biopsy should be used to definitively diagnose lymphoma risk of lymphoma... Data aim to correlate features with prediction targets, such as survival or malignancy11 features with an ICC below is. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 from! Hodgkin 's lymphoma [ J ] modified based on imaging, and several other advanced are... Mauch, P.M. See permissionsforcopyrightquestions and/or permission requests the examination as `` initial '' presented with 95 % interval. Generally considered to indicate statistical significance was administered intravenously official views of the National Institutes of.... The therapeutic strategy Dec ; 24 ( 12 ):2501-2508. doi: 10.1186/s40164-022-00360-4 of all features from the.! Of features was reduced using different techniques ( 1 ):108. doi:.... 2017 May 25 ; 5 ( 5 ): e410-e421 performed to reduce number! Bhatia, S. ; Visakh, A.R prediction targets, such as survival or malignancy11 with.
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